时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
More importantly, it is still unclear whether ANT1 contributes to the initiation and maintenance of PVN neuronal dysfunction during high-salt-induced hypertension and whether it mediates the central antihypertensive effects of electroacupuncture.；Therefore, we hypothesized that EA at the Taichong acupoint may contribute to blood pressure regulation by modulating the abnormal excitability of PVN–RVLM projection neurons.；We hypothesized that the neuronal hyperexcitability of the PVN observed under hypertensive conditions may not be restricted to PVN neurons projecting to the RVLM, but may also extend to PVN neurons projecting to the NTS.
方法
Despite the availability of multiple antihypertensive therapies, a substantial proportion of patients still fail to achieve adequate blood pressure control (3).；Clinical studies further suggest that up to 50% of patients with hypertension exhibit salt sensitivity (5).；Therefore, systematically elucidating the role of ANT1 in the PVN autonomic regulatory network will not only advance our understanding of the central mechanisms linking mitochondrial dysfunction to hypertension but may also identify a novel molecular target underlying the therapeutic effects of electroacupuncture in neurogenic hypertension.2Materials and methods2.1Experimental animalsA total of 48 male C57BL/6J mice aged 7–8 weeks were used in this study.
核心结论
Moreover, the latest Global Burden of Disease (GBD) study indicates that excessive dietary sodium intake remains a major contributor to cardiovascular mortality attributable to unhealthy dietary patterns in China (4).；Clinical studies further suggest that up to 50% of patients with hypertension exhibit salt sensitivity (5).；Furthermore, accumulating evidence has demonstrated that hypertension is frequently accompanied by anxiety-like behaviors, depression, and cognitive impairment, suggesting that central nervous system dysfunction plays a pivotal role in the development and progression of hypertension.The paraventricular nucleus (PVN) of the hypothalamus is a critical integrative center regulating autonomic and neuroendocrine functions and plays a central role in maintaining cardiovascular homeostasis and blood pressure regulation.
局限
However, the precise mechanisms by which EA modulates PVN neuronal excitability and alters central autonomic regulation remain incompletely understood.Mitochondrial dysfunction and oxidative stress have recently been recognized as key pathological mechanisms underlying the development and progression of neurogenic hypertension (18).；More importantly, it is still unclear whether ANT1 contributes to the initiation and maintenance of PVN neuronal dysfunction during high-salt-induced hypertension and whether it mediates the central antihypertensive effects of electroacupuncture.；However, the central neural mechanisms underlying the antihypertensive effects of EA remain unclear.
对本项目的价值
中高价值：属「线粒体质量控制与氧化应激」方向；线粒体功能与氧化应激栏目可用作本项目文献库与综述素材。 ｜ 价值分 3.0/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 73,311 字符，题名指纹 0.88，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：电针经调节小鼠下丘脑室旁核神经元兴奋性与蛋白组签名减轻高盐诱导高血压
- 英文标题：Electroacupuncture attenuates high-salt-induced hypertension by modulating neuronal excitability and proteomic signatures in the paraventricular nucleus of mice.
- 期刊与标识：Frontiers in medicine · PMID 42978707 · DOI 10.3389/fmed.2026.1955943 · PMC PMC13727468