时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
Future studies should combine pathway markers with measurements of proteasomal activity, autophagic flux, and tracer‐based protein synthesis and breakdown to determine whether the net outcome is genuine protein accretion.；In the following sections, we evaluate whether these reported metabolic shifts are consistently associated with changes in muscle composition, protein accretion, or growth performance.；These outcomes indicate changes in muscle composition and fiber‐type‐related gene expression, but they do not establish whether chlorogenic acid increased net protein deposition.
方法
Importantly, these pathways should not be interpreted as uniformly anabolic or catabolic, because their consequences depend on the cell type, physiological or pathological state, compound, dose, and duration of exposure.；Curcumin reduced the expression of the muscle‐specific E3 ubiquitin ligases MuRF1 and Atrogin‐1 in stress‐ or dexamethasone‐treated muscle cells (Lyu et al. 2023; Sani et al. 2021; Shao et al. 2024; Taengthong et al. 2022).；In the following sections, we evaluate whether these reported metabolic shifts are consistently associated with changes in muscle composition, protein accretion, or growth performance.
核心结论
Collectively, these coordinated effects support muscle protein homeostasis and provide a mechanistic basis for the potential application of dietary polyphenols in animal husbandry, food manufacturing, and functional nutritional supplements.statusreleaseddisplay-pdfyesis-olfnois-manuscriptnois-preprintnois-journal-matternois-scannednois-retractednoRevised 2026 Aug 16; Received 2026 Jun 21; Accepted 2026 Sep 11; Collection date 2026 Nov.1.IntroductionPhysiological protein deposition refers to the net accumulation of protein within tissues when protein synthesis exceeds degradation.；Optimizing protein deposition in muscle tissue has been shown to significantly improve the texture and nutritional profile of meat, as demonstrated in studies with Eriocheir sinensis (Zhang, Chi, et al. 2021).；Collectively, these studies highlight the potential of polyphenols in maintaining muscle mass and function.
局限
However, they are largely centered on muscle atrophy, sarcopenia, or human health applications, and do not integrate evidence on physiological protein turnover and net protein deposition across both human and livestock systems.Accordingly, this review extends previous work by shifting the focus from muscle atrophy alone to overall protein turnover and net deposition, and by integrating evidence across molecular mechanisms, metabolic regulation, and multiple experimental models.；However, increases in tissue protein content, muscle mass, or anabolic‐pathway phosphorylation should not automatically be interpreted as direct increases in protein synthesis.；However, changes in ubiquitin‐ligase expression alone do not directly quantify proteasomal activity or whole‐muscle protein breakdown.Polyphenol effects on autophagy are more context dependent.
对本项目的价值
中高价值：属「营养感知—自噬—蛋白稳态轴」方向；mTOR / 自噬 / 蛋白质稳态栏目可用作本项目文献库与综述素材。 ｜ 价值分 3.4/5（★★★☆☆）
全文来源
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原文题录
- 中文题名：膳食多酚调控蛋白沉积与肌肉健康：机制、互作与功能应用
- 英文标题：Dietary Polyphenols as Regulators of Protein Deposition and Muscle Health: Mechanisms, Interactions, and Functional Applications.
- 期刊与标识：Food science & nutrition · PMID 42973792 · DOI 10.1002/fsn3.72487 · PMC PMC13724988