时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
Objective radiologic grading of hypothalamic involvement or postoperative hypothalamic injury was not uniformly available.
方法
Emphasis should shift from aggressive resection to risk-adapted strategies prioritizing functional preservation, structured endocrine follow-up, and careful selection for growth hormone therapy, particularly in patients with residual disease.；Visual impairment and endocrine dysfunction frequently dominate the presentation in both pediatric and adult patients.2,3,8 Endocrine abnormalities are present in a large proportion of patients at diagnosis and reflect involvement of the hypothalamic–pituitary axis.；Several contemporary series and meta-analyses have reported improved visual outcomes and comparable tumor control with transsphenoidal approaches when compared with transcranial surgery (TCS) in selected patients.10,11 Despite these advances, postoperative complications such as cerebrospinal fluid (CSF) leak, meningitis, endocrine deterioration, and hypothalamic dysfunction remain common, and outcomes vary across centers.
核心结论
Overall, 55.22% of patients were younger than 18 years, 27.62% were aged 18 to 40 years, and 17.16% were older than 40 years.；Giant tumors were defined as maximum tumor diameter ≥4 cm.Unusual and Rare Clinical PresentationsSeveral patients in this cohort demonstrated uncommon and atypical presentations of CP, highlighting the protean clinical spectrum of the disease.A young woman with primary amenorrhea presented with progressive ataxia, characterized by gait instability and limb incoordination.；A, Noncontrast axial computed tomography scan demonstrating a partially calcified suprasellar mass.
局限
However, complete tumor removal is often limited by adherence to surrounding critical structures, particularly the hypothalamus.；D, Susceptibility-weighted imaging demonstrating scattered intralesional hypointense foci suggestive of hemorrhagic components.Calcifications on computed tomography were present in 83.7% of cases; however, a subset of tumors lacked detectable calcification on computed tomography despite characteristic MRI features (Fig. 4A and B, Fig. 5A and B).Fig. 4CT imaging of craniopharyngioma.；However, these findings should be interpreted descriptively because RT or GKRS was generally used for residual or recurrent disease rather than as planned upfront adjuvant treatment.Retreatment ModalitiesAmong 165 patients with available retreatment data, 53 (32.1%) required additional intervention after index surgery.
对本项目的价值
中等价值：属「代谢 / 内分泌 / 肝肾老化」方向；代谢 / 内分泌 / 肝肾老化的界面栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 49,425 字符，题名指纹 1.0，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：颅咽管瘤的全程生命周期管理：大样本单中心队列的手术结局、内分泌发病与长期疾病控制
- 英文标题：Craniopharyngioma Across the Lifespan: A Large Single-Center Cohort Study of Surgical Outcomes, Endocrine Morbidity, and Long-Term Disease Control.
- 期刊与标识：AACE endocrinology and diabetes · PMID 42979047 · DOI 10.1016/j.aed.2026.07.015 · PMC PMC13728299