时间标签：数据日期 2026-11-01 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/31–2026/11/01 ｜ 情报发生日期 2026-11-01
研究问题
In this study, we report nationwide excess mortality in all three years of the COVID-19 pandemic period in the Czech Republic (Central Europe).
方法
Despite these drawbacks, a notable strength of our study is that we performed these analyses using officially reported nationwide mortality data for all three COVID-19 pandemic years.；All analyses were performed using the ‘Comparing Two Person-Time Rates’ module in a publicly available application at www.openepi.com . methods and the same period to our study.；The official estimates of the national population size (from the Czech Statistical Office) were used as the denominators for calculations of mortality rates.
核心结论
Our findings are consistent with data from the United Kingdom, which showed a similar pattern with an increased proportion of pandemic deaths occurring at home [ , ].；Oxidative stress and increased inflammation are associated with blood glucose levels and glucose intolerance and accelerate insulin resistance [ , ].；These results could be interpreted as suggesting that the Czech healthcare system was prepared to adequately control the consequences of the pandemic as well as to provide ordinary healthcare.；On the other hand, several selected causes of death (heart failure, diabetes mellitus and Parkinson’s disease) increased by more than 20% when compared with pre-pandemic years.
局限
Strengths and limitations There are several limitations of this study.
对本项目的价值
临床前机制证据，需评估物种外推与剂量可行性：血管老化是全身衰老的先行指标，可与其他时钟做交叉验证。 ｜ 价值分 1.2/5（★☆☆☆☆）
全文来源
PubMed PMC JATS 全文（正文 20,846 字符，已过 DOI 逐字 + 题名指纹双重归属校验）
原文题录
- 英文标题：Excess mortality related to the COVID-19 pandemic by age, sex, and cause of death in the Czech Republic.
- 期刊与标识：BMC public health · PMID 42963572 · DOI 10.1186/s12889-026-29300-1
B 级证据分级：B 级（同行评议临床前研究，主要为动物模型）
本文核心结论来自动物模型或体外细胞学，属临床前证据，不能外推至人体。「延长健康寿命」「改善功能」等表述在小鼠中的意义，与人类临床结局之间仍有距离。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。