时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
However, clinical evidence evaluating such combined strategies in humans remains limited.We hypothesized that daily consumption of a multi-component nutritional supplement would improve endothelial function and related indices of vascular ageing compared with control.；Accordingly, in this randomized, double-blind, controlled trial, we tested whether a formulation selected to combine ingredients with relevance to complementary biological pathways implicated in vascular ageing was associated with changes in endothelial function, arterial stiffness, haemodynamics, lipid profile, and estimated cardiovascular risk in healthy middle-aged and older adults (≥40 years).；Further studies incorporating mechanistic biomarkers, component-deconstruction designs, and longer-term clinical outcomes are required to determine whether the observed vascular changes reflect modulation of ageing-related biology and whether they translate into effects on cardiovascular risk or healthy longevity.Effects on endothelial function and potential mechanismsEndothelial function, assessed by brachial artery FMD, improved at the prespecified 6-month endpoint.
方法
However, clinical evidence evaluating such combined strategies in humans remains limited.We hypothesized that daily consumption of a multi-component nutritional supplement would improve endothelial function and related indices of vascular ageing compared with control.；Accordingly, in this randomized, double-blind, controlled trial, we tested whether a formulation selected to combine ingredients with relevance to complementary biological pathways implicated in vascular ageing was associated with changes in endothelial function, arterial stiffness, haemodynamics, lipid profile, and estimated cardiovascular risk in healthy middle-aged and older adults (≥40 years).；Secondary endpoints included changes in device-derived pulse wave velocity (PWV), peripheral and central blood pressure, blood lipids, and SCORE2/SCORE2-OP-derived cardiovascular risk.MethodsTrial design, participant eligibility criteria and settingThe effects of a supplement to target ageing mechanisms on vascular function study was a single-centre, two-armed parallel group, randomized, controlled, double-blind clinical trial with 1:1 allocation.
核心结论
Chronic changes in PWV inversely correlated with chronic changes in FMD (r = −0.37, P = 0.019).Systolic blood pressure decreased by −8.5 ± 7.0 mmHg at 6 months, whereas the control arm demonstrated a smaller reduction (−1.5 ± 9.6 mmHg).；Together, these findings support further evaluation of the intervention as a potential strategy to attenuate age-associated increases in arterial stiffness.Absence of lipid modulation and implications for cardiovascular risk reductionLipid concentrations were unchanged, indicating that the modest reduction in estimated 10-year cardiovascular risk was not mediated by lipid lowering.
局限
However, clinical evidence evaluating such combined strategies in humans remains limited.We hypothesized that daily consumption of a multi-component nutritional supplement would improve endothelial function and related indices of vascular ageing compared with control.；However, the study did not include mechanistic endpoints and therefore cannot determine which component(s), combinations of components, or downstream pathways contributed to the observed vascular effects.；Further studies incorporating mechanistic biomarkers, component-deconstruction designs, and longer-term clinical outcomes are required to determine whether the observed vascular changes reflect modulation of ageing-related biology and whether they translate into effects on cardiovascular risk or healthy longevity.Effects on endothelial function and potential mechanismsEndothelial function, assessed by brachial artery FMD, improved at the prespecified 6-month endpoint.
对本项目的价值
中等价值：属「血管 / 心血管老化」方向；血管 / 心血管老化栏目可用作本项目文献库与综述素材。 ｜ 价值分 2.6/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 38,737 字符，题名指纹 1.0，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：多组分营养补充剂的急性与 6 个月血管效应：随机对照试验
- 英文标题：Acute and 6-month vascular effects of a multi-component nutritional supplement: a randomized controlled trial.
- 期刊与标识：European heart journal open · PMID 42979377 · DOI 10.1093/ehjopen/oeag157 · PMC PMC13730552