时间标签：数据日期 2026-10-31 · 生成时间 2026-11-01 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/10/28–2026/10/31 ｜ 情报发生日期 2026-10-31
研究问题
Given the inherent challenges of invasive left ventricular (LV) catheterization for PVL quantification, non-invasive methods using echocardiography and magnetic resonance imaging have gained prominence and been validated against invasive measurements [, ].；We hypothesized that incorporating a measure of arterial stiffness would improve LVESP prediction across the lifespan.
方法
Physiologically plausible individuals were retained by excluding subjects (N = 537) with simulated aortic or brachial BPs outside the 99% age-specific confidence intervals of reference healthy values [].；Values predicted in the validation cohort using this methodology are denoted LVESPRF.；LVESP was also predicted using the equations described by Kelly et al. in the validation cohort []:0.9 × SBP (LVESP0.9xSBP)2/3 SBP + 1/3 DBP (LVESP2/3SBP+1/3DBP) Variables were assessed for normality using Q-Q plots and quantitatively with the Shapiro–Wilk test.；Statistical significance was defined as P < 0.05.
核心结论
LVESPsim increased from 95 ± 7 mmHg at age 25 to 107 ± 8 mmHg at age 75.；Brachial SBP and cfPWV followed a similar trend, whilst brachial DBP decreased from 72 ± 6 to 69 ± 7 mmHg.；Before model development, 767 patients were withheld as the internal hold-out validation cohort, which showed no significant differences with the remaining 3,070 patients in the derivation set (Supplementary Table 1). ‖ 结论：These results warrant validation in vivo to ascertain real-world predictive performance.
局限
In the present study, we found that LVESP0.9xSBP and LVESP2/3SBP+1/3DBP were strongly correlated with LVESP, albeit less so than LVESPRF and LVESPLASSO, demonstrating that these simple equations remain broadly valid provided their limitations are considered.；This is exemplified in our healthy cohort as there are no co-morbidities associated with arterial stiffness that could confound this relationship [].；This suggests that non-invasive LVESP estimation may be less accurate at higher pressures and that LVESP2/3SBP+1/3DBP should be used with caution in populations with elevated LVESP, such as patients with hypertension.
对本项目的价值
★☆☆☆☆ 方法学进展决定我们能否在有限样本下检出真实效应，属基础设施级收益。最大样本量约 3,837。
全文来源
PMC JATS 全文（正文 22,426 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Artificial intelligence-enabled non-invasive quantification of left ventricular end-systolic pressure: an in silico analysis.
- 期刊与标识：BMC Cardiovasc Disord · PMID 42958052 · DOI 10.1186/s12872-026-06358-8
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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