时间标签：数据日期 2026-11-05 · 生成时间 2026-11-05 05:30（Asia/Shanghai）｜ 检索窗口 PubMed edat 2026/11/02 – 2026/11/06 ｜ 情报发生日期 2026-11-05
研究问题
The encapsulation of BS was characterized using a confocal laser scanning microscope (CLSM, LeicaTCSSP8, Germany), UV–vis spectroscopy (Shimadzu instrument, Japan), and FTIR spectroscopy (Fisher Nicolet 2000, USA).2.4Bacterial viability assayTo assess whether the surface coating affects the growth and proliferation of BS, the growth curves of different preparations were measured.；Furthermore, we investigated the entrapment efficiency and drug loading efficiency of BBR, which were 97.5% and 0.297 mg/108 CFU when the BBR concentration reached 0.3 mg/mL (Supporting Information Fig.；We further used immunohistochemical analysis of myeloperoxidase (MPO) to investigate whether BS@MPN-BBR@S100 could reduce neutrophil infiltration.
方法
1IntroductionInflammatory bowel disease (IBD) is a condition that seriously reduces patients’ quality of life, confers a 5- to 8- fold increase in colorectal cancer risk, and poses a substantial global public health challenge1, 2, 3.；AhR activation promotes interleukin-22 (IL-22) secretion36,37, thereby enhancing intestinal barrier defense through up-regulation of tight-junction proteins, stimulation of mucin secretion, and enhancement of antimicrobial peptide expression38.Here, we report an MPN-armored, probiotic–drug codelivery system (BS@MPN-BBR@S100) designed to synergistically remodel tryptophan metabolism and restore microbiota homeostasis for the treatment of IBD.；These combined effects lead to pronounced alleviation of DSS and TNBS-induced colitis in mice.
核心结论
For example, the metal–phenolic network (MPN) is an ordered mesoporous structure that has been demonstrated to form biocompatible coatings on bacterial surfaces through cross-linking, conferring probiotics with exceptional properties such as anti-oxidation and adhesion21, 22, 23.；Besides, CLSM images demonstrated the stripping of the TA coating from BS@MPN after exposure to CP, as evidenced by a sharp decrease in surface fluorescence (red) (Supporting Information Fig.；These results showed that TA can be specifically degraded by CP, which provides an opportunity for the controlled release of BBR.
局限
However, therapeutics relying solely on probiotic-mediated remodeling of the gut microbiota may exhibit limited efficacy due to the disrupted intestinal barrier, resulting in severe inflammatory infiltration24, 25, 26.；However, the other control groups showed little effect (Fig. 5N–P, R–T).；However, BS@MPN-BBR@S100 downregulated the abundance of Clostridia_UCG-014 (Fig. 6I)67.
对本项目的价值
中高价值：属「线粒体质量控制与氧化应激」方向；线粒体功能与氧化应激栏目可用作本项目文献库与综述素材。 ｜ 价值分 3.0/5（★★★☆☆）
全文来源
PubMed PMC JATS（正文 50,681 字符，题名指纹 0.93，已过 PubMed PMCID 官方关联 + 题名指纹 + 正文长度归属校验）
原文题录
- 中文题名：经色氨酸代谢与菌群重塑的益生菌-药物级联系统治疗炎症性肠病
- 英文标题：A probiotic-drug cascade system for inflammatory bowel disease via tryptophan metabolism and gut microbiome remodeling.
- 期刊与标识：Acta pharmaceutica Sinica. B · PMID 42979275 · DOI 10.1016/j.apsb.2026.07.013 · PMC PMC13730227