Senolytic

Drugs that selectively clear senescent cells

What is Senolytic?

Senolytic drugs are a class of drugs that selectively eliminate senescent cells. Senescent cells accumulate with age and secrete harmful SASP factors, contributing to aging and age-related diseases.

Key senolytic agents include NMN, Metformin, and natural flavonoids like Fisetin and Quercetin.

Clinical Trials

NCT04685590 - Senolytic

Alzheimer's Disease • Washington University

Recruiting

NCT02848131 - Senolytic

Chronic Kidney Disease • Mayo Clinic

Recruiting

NCT06133634 - Fisetin

Vascular Function • University of Colorado

Active

NCT04063124 - Senolytic

Alzheimer's Disease • University of Texas

Completed