🧬 长寿科技简报

ANKRD1 Gene Therapy Improves Memory Function in Aged Mice

Neurogenesis is the creation of new neurons from stem cell populations, followed by the integration of these newly created cells into existing neural networks. Neurogenesis is required for memory and learning to take place in the adult brain, and is thought to provide an important contribution to wh

The Hypoxia Response as an Example of the Way in Which Mild Stressors Slow Aging

Researchers have demonstrated that many forms of mild, repeated stresses can improve cell function and slow aging. Lack of nutrients, lack of oxygen, heat, cold, oxidative damage, and others have been demonstrated to be beneficial in animal studies. Here, researchers discuss what is known of the res

A View of the Present State of the Comparative Biology of Aging

The study of aging is an ongoing project, as is the study of cellular metabolism. The research community remains some way from a complete understanding, and as such there is a great deal of ongoing empirical discovery. Popular areas of study exist because someone demonstrated that a particular appro

Complement System Biomarkers Change with Age, and More So in Dementia Patients

The immune system changes with age, a mix of damage and reactions to that damage. Some of those reactions make things better and some are maladaptive, making things worse. Immune cell populations change in size, and immune cells themselves carry burdens of dysfunction, the usual forms of damage and

Electric Fields Allow Bioprinting of Aligned Muscle Fibers

Bioprinting even small sections of replacement tissue faces a range of challenges relating to recapturing the small-scale structure of natural tissues. The formation of blood vessels is a particularly thorny issue that can be bypassed in some circumstances, such as rebuilding muscle following injury

A SEMA7A Feedback Loop in Macrophages Accelerates Atherosclerosis

Perhaps the most useful way to think of atherosclerosis, the ultimately fatal growth of fatty plaques in blood vessel walls, is as a condition driven by macrophage dysfunction. Macrophages are innate immune cells responsible for repair and maintenance in blood vessel walls. Where blood vessels are d

Fight Aging! Newsletter, March 9th 2026

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter, please vi

Reviewing What is Known of the Virome in Aging

The human body hosts countless viruses in addition to the other forms of microbe such as bacteria and fungi. Most of these viruses are commensal species, most likely harmless throughout much or all of the life span, playing their parts in the microbial ecosystems that exist within and around the bod

FMO-2 Upregulation is Common to Multiple Longevity Associated Mutations in Nematodes

Research into the biochemistry of longevity does not proceed at a rapid pace, even now that the field has become popular. Much of this research takes the form of first discovering longevity-enhancing mutations in short-lived species and then painstakingly tracing chains of cause and effect from prot

More Confirming Data for Adult Human Neurogenesis

That new neurons are generated in the adult brain and integrate into existing neural networks was first established in mice in the 1990s, but considerable debate has taken place since then as to whether this adult neurogenesis also occurs in humans. Working with human brain tissue has always been lo

Scientists Successfully Freeze and Rewarm Mouse Brain Slices

In a new study, researchers have vitrified mouse brain slices and then a complete brain with encouraging results: upon rewarming, much of the neuronal function was preserved [1]. The bumpy road to cryopreservation […]

A Review of How the Heart Ages

The European Heart Journal has published a review of what happens to the human heart as it ages, noting the cellular effects of mitochondrial dysfunction and cellular senescence […]

Fat Composition Affects T Cell-Mediated Immunity

Scientists have found that the ratio between poly- and monounsaturated fatty acids affects the viability of T cells as well as both humoral and anti-tumor immunity [1]. The iron death Some fats are broadly […]

How Inflammaging Makes Pneumonia Worse in Mice

Researchers publishing in Aging Cell have discovered how older organisms’ susceptibility to pneumonia is related to inflammatory factors. Short-lived infection fighters Polymorphonuclear leukocytes, more commonly known as neutrophils, are part of the first line of defense […]

Resistance Exercise Training Slows Down Brain Aging

Using brain clock models that analyzed MRI images of the brains of elderly people who underwent one year of resistance training, researchers concluded that both heavy and moderate resistance […]

Novel Mechanism for Parkinson’s Is Linked to ATP Deficiency

Scientists have discovered that ATP deficiency disrupts dopamine processing in synapses, leading to the accumulation of the harmful protein species that characterize Parkinson’s disease. ATP supplementation helps, but the road […]

Rejuvenation Roundup February 2026

Plenty of crucial work has been done in the rejuvenation world over the past four weeks, and last month, we’ve spoken […]

Cellular Reprogramming: The Expert Roundup

Cellular reprogramming is one of the technologies most associated with longevity. The field was created in 2006, when Shinya Yamanaka showed that […]

A Metabolic Shift Fuels Stem Cell Dysfunction

Researchers publishing in the Nature journal Cell Discovery have described how the age-related attenuation of a key metabolic axis causes human adipose-derived stem cells (hASCs) to lose functional capabilities. Pinpointing […]

João Pedro de Magalhães on the Ethics of Longevity

João Pedro de Magalhães, professor at the University of Birmingham, is known as a prominent geroscientist who has been in the field forever, enriching it with top-tier research. He is also a skilled longevity […]

抗衰老策略综述

当前抗衰老研究主要集中在：Senolytic 药物（清除衰老细胞）、NAD+ 前体补充、端粒酶激活、mTOR 抑制等策略。多项临床试验正在进行中。

• 抗衰老生物科技公司持续获融资
• AI 辅助药物设计加速新靶点发现
• 多项临床试验进入关键阶段