{
 "fetchedAt": "2026-10-11T10:29:19Z",
 "source": "ClinicalTrials.gov API v2",
 "sourceUrl": "https://clinicaltrials.gov/",
 "total": 82,
 "dedupSkipped": 6,
 "groups": {
  "senolytic": {
   "label": "Senolytics 衰老细胞清除",
   "count": 14,
   "trials": [
    {
     "nct": "NCT07637487",
     "title": "Tocotrienol Supplementa as A Senolytic Agent in Middle-aged Adults",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "NA",
     "enroll": "220",
     "enrollType": "",
     "conditions": [
      "Healthy"
     ],
     "interventions": [
      "Treatment",
      "Placebo"
     ],
     "countries": [
      "Malaysia"
     ],
     "lastUpdate": "2026-06-09",
     "statusVerified": "2026-06-01",
     "startDate": "2023-10-31",
     "completionDate": "2027-01-30",
     "url": "https://clinicaltrials.gov/study/NCT07637487"
    },
    {
     "nct": "NCT06399809",
     "title": "Fisetin to Reduce Senescence and Mobility Impairment in PAD",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "PHASE2",
     "enroll": "34",
     "enrollType": "",
     "conditions": [
      "Peripheral Arterial Disease",
      "Aging",
      "Peripheral Vascular Diseases",
      "Walking, Difficulty"
     ],
     "interventions": [
      "Fisetin",
      "Placebo"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-04-15",
     "statusVerified": "2026-04-01",
     "startDate": "2024-09-30",
     "completionDate": "2027-06-01",
     "url": "https://clinicaltrials.gov/study/NCT06399809"
    },
    {
     "nct": "NCT05653258",
     "title": "Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "PHASE2 / PHASE3",
     "enroll": "160",
     "enrollType": "",
     "conditions": [
      "Obesity",
      "Healthy Lifestyle"
     ],
     "interventions": [
      "Lifestyle Intervention",
      "Dasatinib 100 MG",
      "Quercetin 1000mg",
      "Placebo"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-03-18",
     "statusVerified": "2026-03-01",
     "startDate": "2023-10-17",
     "completionDate": "2028-02-01",
     "url": "https://clinicaltrials.gov/study/NCT05653258"
    },
    {
     "nct": "NCT06135870",
     "title": "Role of Senescent Cells in Uterine Fibroid Pathogenesis (SOUL Study)",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "未标注分期",
     "enroll": "150",
     "enrollType": "",
     "conditions": [
      "Fibroid",
      "Leiomyoma"
     ],
     "interventions": [],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2025-12-11",
     "statusVerified": "2025-12-01",
     "startDate": "2023-11-01",
     "completionDate": "2027-12-31",
     "url": "https://clinicaltrials.gov/study/NCT06135870"
    },
    {
     "nct": "NCT06133634",
     "title": "Fisetin to Improve Vascular Function in Older Adults",
     "org": "未标注",
     "status": "进行中（不再招募）",
     "statusRaw": "ACTIVE_NOT_RECRUITING",
     "statusClass": "active",
     "phase": "PHASE1 / PHASE2",
     "enroll": "70",
     "enrollType": "",
     "conditions": [
      "Aging",
      "Endothelial Dysfunction",
      "Arterial Stiffness"
     ],
     "interventions": [
      "Fisetin",
      "Placebo"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-09-25",
     "statusVerified": "2026-09-01",
     "startDate": "2023-09-25",
     "completionDate": "2027-03-31",
     "url": "https://clinicaltrials.gov/study/NCT06133634"
    },
    {
     "nct": "NCT02848131",
     "title": "Senescence in Chronic Kidney Disease",
     "org": "未标注",
     "status": "定向邀请入组",
     "statusRaw": "ENROLLING_BY_INVITATION",
     "statusClass": "active",
     "phase": "PHASE2",
     "enroll": "30",
     "enrollType": "",
     "conditions": [
      "Chronic Kidney Disease"
     ],
     "interventions": [
      "Group 2: Dasatinib",
      "Group 2: Quercetin"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-05-19",
     "statusVerified": "2026-05-01",
     "startDate": "2016-07-01",
     "completionDate": "2027-04-01",
     "url": "https://clinicaltrials.gov/study/NCT02848131"
    },
    {
     "nct": "NCT05838560",
     "title": "Dasatinib Plus Quercetin for Accelerated Aging in Mental Disorders",
     "org": "未标注",
     "status": "进行中（不再招募）",
     "statusRaw": "ACTIVE_NOT_RECRUITING",
     "statusClass": "active",
     "phase": "PHASE2",
     "enroll": "40",
     "enrollType": "",
     "conditions": [
      "Schizophrenia",
      "Treatment Resistant Depression",
      "Aging, Premature"
     ],
     "interventions": [
      "Dasatinib",
      "quercetin"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-04-21",
     "statusVerified": "2026-04-01",
     "startDate": "2023-07-01",
     "completionDate": "2027-10-01",
     "url": "https://clinicaltrials.gov/study/NCT05838560"
    },
    {
     "nct": "NCT07144293",
     "title": "Improving Physical Ability and Cellular Senescence Elimination in HIV",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "PHASE2",
     "enroll": "82",
     "enrollType": "",
     "conditions": [
      "HIV",
      "Frailty",
      "Prefrail",
      "Aging Problems"
     ],
     "interventions": [
      "Dasatinib",
      "Quercetin",
      "Placebo - Dasatinib",
      "Placebo - Quercetin"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-09-15",
     "statusVerified": "2026-09-01",
     "startDate": "2025-12-04",
     "completionDate": "2026-08-26",
     "url": "https://clinicaltrials.gov/study/NCT07144293"
    },
    {
     "nct": "NCT07000734",
     "title": "Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pilot Study",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "PHASE2",
     "enroll": "23",
     "enrollType": "",
     "conditions": [
      "Aging",
      "Cognitive Decline",
      "Older Adults",
      "Cardiovascular"
     ],
     "interventions": [
      "Risk managment",
      "Dasatinib",
      "Quercetin (dietary supplement)",
      "Vortioxetine"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-08-19",
     "statusVerified": "2026-08-01",
     "startDate": "2025-07-28",
     "completionDate": "2026-04-30",
     "url": "https://clinicaltrials.gov/study/NCT07000734"
    },
    {
     "nct": "NCT05422885",
     "title": "Safety and Feasibility of Dasatinib and Quercetin in Adults at Risk for Alzheimer's Disease",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "PHASE1 / PHASE2",
     "enroll": "15",
     "enrollType": "",
     "conditions": [
      "Aging"
     ],
     "interventions": [
      "Dasatinib",
      "Quercetin"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2025-03-17",
     "statusVerified": "2025-02-01",
     "startDate": "2022-05-20",
     "completionDate": "2024-01-24",
     "url": "https://clinicaltrials.gov/study/NCT05422885"
    },
    {
     "nct": "NCT04313634",
     "title": "Targeting Cellular Senescence With Senolytics to Improve Skeletal Health in Older Humans",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "PHASE2",
     "enroll": "74",
     "enrollType": "",
     "conditions": [
      "Healthy"
     ],
     "interventions": [
      "Dasatinib",
      "Quercetin",
      "Fisetin"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2024-07-22",
     "statusVerified": "2024-07-01",
     "startDate": "2020-06-09",
     "completionDate": "2023-06-06",
     "url": "https://clinicaltrials.gov/study/NCT04313634"
    },
    {
     "nct": "NCT04770064",
     "title": "Targeting Senescence to Reduce Osteoarthritis Pain and cartilagE Breakdown (ROPE)",
     "org": "未标注",
     "status": "已撤回",
     "statusRaw": "WITHDRAWN",
     "statusClass": "terminated",
     "phase": "PHASE1 / PHASE2",
     "enroll": "0",
     "enrollType": "",
     "conditions": [
      "Osteoarthritis, Knee"
     ],
     "interventions": [
      "High-dose/short-duration Fisetin",
      "Low-dose/sustained-duration Fisetin",
      "Oral placebo capsule"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2022-07-29",
     "statusVerified": "2022-07-01",
     "startDate": "2023-06-01",
     "completionDate": "2024-05-31",
     "url": "https://clinicaltrials.gov/study/NCT04770064"
    },
    {
     "nct": "NCT04994561",
     "title": "VIAging Deceleration Trial Using Metformin, Dasatinib, Rapamycin and Nutritional Supplements",
     "org": "未标注",
     "status": "已撤回",
     "statusRaw": "WITHDRAWN",
     "statusClass": "terminated",
     "phase": "PHASE1",
     "enroll": "0",
     "enrollType": "",
     "conditions": [
      "Aging"
     ],
     "interventions": [
      "Study Drugs and Nutritional Supplements"
     ],
     "countries": [],
     "lastUpdate": "2022-06-07",
     "statusVerified": "2022-06-01",
     "startDate": "2022-06-01",
     "completionDate": "2023-12-01",
     "url": "https://clinicaltrials.gov/study/NCT04994561"
    },
    {
     "nct": "NCT04946383",
     "title": "Safety and Effectivness of Quercetin & Dasatinib on Epigenetic Aging",
     "org": "未标注",
     "status": "UNKNOWN",
     "statusRaw": "UNKNOWN",
     "statusClass": "unknown",
     "phase": "PHASE2",
     "enroll": "25",
     "enrollType": "",
     "conditions": [
      "Aging"
     ],
     "interventions": [
      "Dasatinib plus Quercetin"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2021-08-03",
     "statusVerified": "2021-08-01",
     "startDate": "2020-12-16",
     "completionDate": "2022-06-30",
     "url": "https://clinicaltrials.gov/study/NCT04946383"
    }
   ]
  },
  "nmn": {
   "label": "NMN / NAD+ 前体",
   "count": 25,
   "trials": [
    {
     "nct": "NCT07144527",
     "title": "Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "NA",
     "enroll": "40",
     "enrollType": "",
     "conditions": [
      "Aging",
      "Frailty",
      "Exercise Tolerance",
      "Healthy Male and Female Subjects"
     ],
     "interventions": [
      "NMN and TMG (Euexia)",
      "Nicotinamide Mononucleotide (NMN)",
      "Placebo"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-10-07",
     "statusVerified": "2026-02-01",
     "startDate": "2026-02-21",
     "completionDate": "2027-01-01",
     "url": "https://clinicaltrials.gov/study/NCT07144527"
    },
    {
     "nct": "NCT07416786",
     "title": "Validation of NAD+ Measurements for Human Clinical Studies",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "NA",
     "enroll": "48",
     "enrollType": "",
     "conditions": [
      "Healthy Adults"
     ],
     "interventions": [
      "Oral NR Supplementation"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-09-11",
     "statusVerified": "2026-09-01",
     "startDate": "2026-09-01",
     "completionDate": "2028-07-31",
     "url": "https://clinicaltrials.gov/study/NCT07416786"
    },
    {
     "nct": "NCT07073352",
     "title": "ACEs, SIRT1, and Premature Vascular Aging in Humans",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "NA",
     "enroll": "30",
     "enrollType": "",
     "conditions": [
      "Adverse Childhood Experiences",
      "Endothelial Dysfunction"
     ],
     "interventions": [
      "Nicotinamide Riboside",
      "Placebo"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-08-19",
     "statusVerified": "2026-08-01",
     "startDate": "2025-03-27",
     "completionDate": "2027-06-30",
     "url": "https://clinicaltrials.gov/study/NCT07073352"
    },
    {
     "nct": "NCT06592859",
     "title": "Intervention of Nicotinamide Mononucleotide in Middle-aged and Elderly People",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "NA",
     "enroll": "240",
     "enrollType": "",
     "conditions": [
      "Aging",
      "NMN"
     ],
     "interventions": [
      "NMN",
      "placebo"
     ],
     "countries": [
      "China"
     ],
     "lastUpdate": "2026-05-08",
     "statusVerified": "2026-03-01",
     "startDate": "2023-08-23",
     "completionDate": "2026-12-31",
     "url": "https://clinicaltrials.gov/study/NCT06592859"
    },
    {
     "nct": "NCT05483465",
     "title": "The Effect of NAD Supplementation on Brain Vascular Health in Aging",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "PHASE4",
     "enroll": "214",
     "enrollType": "",
     "conditions": [
      "Aging"
     ],
     "interventions": [
      "Nicotinamide riboside",
      "Placebo"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-04-01",
     "statusVerified": "2026-03-01",
     "startDate": "2023-05-03",
     "completionDate": "2027-12-01",
     "url": "https://clinicaltrials.gov/study/NCT05483465"
    },
    {
     "nct": "NCT07451496",
     "title": "PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "NA",
     "enroll": "20",
     "enrollType": "",
     "conditions": [
      "Ageing"
     ],
     "interventions": [
      "Sleep and dietary counseling",
      "Supervised exercise and exergaming program",
      "Motivational interviewing",
      "Whey protein"
     ],
     "countries": [
      "Singapore"
     ],
     "lastUpdate": "2026-03-05",
     "statusVerified": "2026-02-01",
     "startDate": "2025-09-29",
     "completionDate": "2026-06-30",
     "url": "https://clinicaltrials.gov/study/NCT07451496"
    },
    {
     "nct": "NCT06425042",
     "title": "Nicotinamide Riboside Supplementation and Exercise Training to Promote Healthy Longevity",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "NA",
     "enroll": "28",
     "enrollType": "",
     "conditions": [
      "Healthy Aging",
      "Lifestyle-related Condition",
      "Metabolic Diseases"
     ],
     "interventions": [
      "Nicotinamide Riboside (NR)",
      "Placebo"
     ],
     "countries": [
      "Chile"
     ],
     "lastUpdate": "2025-07-11",
     "statusVerified": "2025-07-01",
     "startDate": "2024-03-01",
     "completionDate": "2026-03-01",
     "url": "https://clinicaltrials.gov/study/NCT06425042"
    },
    {
     "nct": "NCT06907329",
     "title": "The Impact of Nicotinamide Mononucleotide Sustained-release Tablets on Immunosenescence and Metablism in Middle-aged and Elderly Individuals With Metabolic Disorders.",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "NA",
     "enroll": "126",
     "enrollType": "",
     "conditions": [
      "Immunosenescence",
      "Metabolism"
     ],
     "interventions": [
      "NMN",
      "Placebo"
     ],
     "countries": [
      "China"
     ],
     "lastUpdate": "2025-07-08",
     "statusVerified": "2025-06-01",
     "startDate": "2025-06-05",
     "completionDate": "2027-03-31",
     "url": "https://clinicaltrials.gov/study/NCT06907329"
    },
    {
     "nct": "NCT06919328",
     "title": "Absorption and Tolerability of Injectable Administration of Niagen®+, as Compared to NAD+",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "NA",
     "enroll": "70",
     "enrollType": "",
     "conditions": [
      "Healthy Aging"
     ],
     "interventions": [
      "Niagen®",
      "NAD+",
      "Placebo"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2025-04-09",
     "statusVerified": "2025-04-01",
     "startDate": "2024-10-31",
     "completionDate": "2025-06-30",
     "url": "https://clinicaltrials.gov/study/NCT06919328"
    },
    {
     "nct": "NCT06208527",
     "title": "The NADage Study: Nicotinamide Riboside Replenishment Therapy Against Functional Decline in Aging",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "PHASE2",
     "enroll": "100",
     "enrollType": "",
     "conditions": [
      "Frailty",
      "Frail Elderly Syndrome",
      "Frailty Syndrome",
      "Aging"
     ],
     "interventions": [
      "Nicotinamide Riboside (NR)",
      "Placebo"
     ],
     "countries": [
      "Norway"
     ],
     "lastUpdate": "2025-01-20",
     "statusVerified": "2024-12-01",
     "startDate": "2025-01-01",
     "completionDate": "2030-12-01",
     "url": "https://clinicaltrials.gov/study/NCT06208527"
    },
    {
     "nct": "NCT03821623",
     "title": "Nicotinamide Riboside for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults",
     "org": "未标注",
     "status": "进行中（不再招募）",
     "statusRaw": "ACTIVE_NOT_RECRUITING",
     "statusClass": "active",
     "phase": "PHASE2",
     "enroll": "118",
     "enrollType": "",
     "conditions": [
      "Hypertension",
      "Aging"
     ],
     "interventions": [
      "Nicotinamide riboside",
      "Placebo"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-10-02",
     "statusVerified": "2026-09-01",
     "startDate": "2019-05-10",
     "completionDate": "2027-10-01",
     "url": "https://clinicaltrials.gov/study/NCT03821623"
    },
    {
     "nct": "NCT06345443",
     "title": "NRM on Vascular Perfusion in Healthy Adults",
     "org": "未标注",
     "status": "定向邀请入组",
     "statusRaw": "ENROLLING_BY_INVITATION",
     "statusClass": "active",
     "phase": "NA",
     "enroll": "200",
     "enrollType": "",
     "conditions": [
      "Vascular Stiffness"
     ],
     "interventions": [
      "Nicotinamide Riboside Malate",
      "Placebo"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-03-18",
     "statusVerified": "2026-03-01",
     "startDate": "2024-11-25",
     "completionDate": "2026-12-31",
     "url": "https://clinicaltrials.gov/study/NCT06345443"
    },
    {
     "nct": "NCT06889740",
     "title": "Evaluate the Safety, Tolerability, and Efficacy of UthPeak NMNH (Reduced Nicotinamide Mononucleotide) in Healthy Adult Participants",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "NA",
     "enroll": "80",
     "enrollType": "",
     "conditions": [
      "Healthy Aging"
     ],
     "interventions": [
      "NMNH",
      "Placebo"
     ],
     "countries": [
      "India"
     ],
     "lastUpdate": "2025-07-04",
     "statusVerified": "2025-07-01",
     "startDate": "2024-07-08",
     "completionDate": "2025-01-25",
     "url": "https://clinicaltrials.gov/study/NCT06889740"
    },
    {
     "nct": "NCT05517122",
     "title": "Effect of Oral NAD+ Precursors Administration on Blood NAD+ Concentration in Healthy Adults",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "NA",
     "enroll": "68",
     "enrollType": "",
     "conditions": [
      "Healthy"
     ],
     "interventions": [
      "Nicotinamide (NAM)",
      "Nicotinamide Riboside (NR)",
      "Nicotinamide Mono Nucleotide (NMN)",
      "Microcrystalline cellulose"
     ],
     "countries": [
      "Switzerland"
     ],
     "lastUpdate": "2025-04-24",
     "statusVerified": "2025-04-01",
     "startDate": "2022-07-12",
     "completionDate": "2022-11-24",
     "url": "https://clinicaltrials.gov/study/NCT05517122"
    },
    {
     "nct": "NCT03818802",
     "title": "Effects of Vitamin B3 Derivative Nicotinamide Riboside (NR) in Bone, Skeletal Muscle and Metabolic Functions in Aging",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "NA",
     "enroll": "53",
     "enrollType": "",
     "conditions": [
      "Healthy Elderly Volunteers"
     ],
     "interventions": [
      "Nicotinamide Riboside",
      "Placebo"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2025-02-26",
     "statusVerified": "2024-04-01",
     "startDate": "2019-09-16",
     "completionDate": "2024-11-08",
     "url": "https://clinicaltrials.gov/study/NCT03818802"
    },
    {
     "nct": "NCT04112043",
     "title": "Nicotinamide Riboside as an Enhancer of Exercise Therapy in Hypertensive Older Adults (The NEET Trial)",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "PHASE1",
     "enroll": "147",
     "enrollType": "",
     "conditions": [
      "Hypertension"
     ],
     "interventions": [
      "Walking Exercise",
      "Nicotinamide Riboside (NR)"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2024-06-06",
     "statusVerified": "2024-05-01",
     "startDate": "2020-07-28",
     "completionDate": "2023-05-26",
     "url": "https://clinicaltrials.gov/study/NCT04112043"
    },
    {
     "nct": "NCT05593939",
     "title": "Slow Age: Interventions to Slow Aging in Humans",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "PHASE2",
     "enroll": "80",
     "enrollType": "",
     "conditions": [
      "Aging"
     ],
     "interventions": [
      "Exercise",
      "Time restricted feeding",
      "Nicotinamide riboside"
     ],
     "countries": [
      "Denmark"
     ],
     "lastUpdate": "2023-04-25",
     "statusVerified": "2022-09-01",
     "startDate": "2022-05-01",
     "completionDate": "2022-12-21",
     "url": "https://clinicaltrials.gov/study/NCT05593939"
    },
    {
     "nct": "NCT04823260",
     "title": "To Evaluate the Efficacy and Safety of NMN as an Anti-ageing Supplement in Middle Aged and Older (40-65 Years) Adults",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "NA",
     "enroll": "90",
     "enrollType": "",
     "conditions": [
      "Aging"
     ],
     "interventions": [
      "Nicotinamide Mononucleotide",
      "Placebo"
     ],
     "countries": [
      "India"
     ],
     "lastUpdate": "2021-10-01",
     "statusVerified": "2021-09-01",
     "startDate": "2021-05-25",
     "completionDate": "2021-09-09",
     "url": "https://clinicaltrials.gov/study/NCT04823260"
    },
    {
     "nct": "NCT04228640",
     "title": "Evaluate the Efficacy and Safety of Uthever NMN(Nicotinamide Mononucleotide, a Form of Vitamin B3)",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "NA",
     "enroll": "66",
     "enrollType": "",
     "conditions": [
      "Aging"
     ],
     "interventions": [
      "NMN",
      "Placebo"
     ],
     "countries": [
      "India"
     ],
     "lastUpdate": "2021-04-01",
     "statusVerified": "2021-03-01",
     "startDate": "2020-12-15",
     "completionDate": "2021-03-30",
     "url": "https://clinicaltrials.gov/study/NCT04228640"
    },
    {
     "nct": "NCT03754842",
     "title": "Effect of Nicotinamide Riboside and Pterostilbene Supplementation on Muscle Regeneration in Elderly Humans",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "NA",
     "enroll": "32",
     "enrollType": "",
     "conditions": [
      "Muscle Injury"
     ],
     "interventions": [
      "Placebo (twice daily)",
      "Nicotinamide Riboside/Pterostilbene (500 mg/100 mg twice daily)"
     ],
     "countries": [
      "Denmark"
     ],
     "lastUpdate": "2020-11-05",
     "statusVerified": "2020-03-01",
     "startDate": "2019-02-12",
     "completionDate": "2020-09-01",
     "url": "https://clinicaltrials.gov/study/NCT03754842"
    },
    {
     "nct": "NCT03501433",
     "title": "Effects of Nicotinamide Riboside on Metabolism and Vascular Function",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "NA",
     "enroll": "16",
     "enrollType": "",
     "conditions": [
      "Aging",
      "Lipemia"
     ],
     "interventions": [
      "Nicotinamide riboside chloride (Niagen)",
      "Placebo"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2020-09-25",
     "statusVerified": "2020-09-01",
     "startDate": "2018-02-01",
     "completionDate": "2019-12-01",
     "url": "https://clinicaltrials.gov/study/NCT03501433"
    },
    {
     "nct": "NCT02921659",
     "title": "Safety & Efficacy of Nicotinamide Riboside Supplementation for Improving Physiological Function in Middle-Aged and Older Adults",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "PHASE1 / PHASE2",
     "enroll": "30",
     "enrollType": "",
     "conditions": [
      "Aging"
     ],
     "interventions": [
      "Niagen™",
      "Placebo"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2016-12-01",
     "statusVerified": "2016-11-01",
     "startDate": "2015-04-01",
     "completionDate": "2016-10-01",
     "url": "https://clinicaltrials.gov/study/NCT02921659"
    },
    {
     "nct": "NCT06382688",
     "title": "IV Administration of ChromaDex's Niagen® as Compared to NAD+",
     "org": "未标注",
     "status": "UNKNOWN",
     "statusRaw": "UNKNOWN",
     "statusClass": "unknown",
     "phase": "NA",
     "enroll": "53",
     "enrollType": "",
     "conditions": [
      "Healthy Aging"
     ],
     "interventions": [
      "NAD+ (nicotinamide adenine dinucleotide) IV",
      "Niagen® (nicotinamide riboside) IV",
      "Niagen® (nicotinamide riboside) oral",
      "Placebo"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2024-04-24",
     "statusVerified": "2024-04-01",
     "startDate": "2023-11-13",
     "completionDate": "2024-08-31",
     "url": "https://clinicaltrials.gov/study/NCT06382688"
    },
    {
     "nct": "NCT05984550",
     "title": "The Exploratory Study on the Nicotinamide Mononucleotide (Vital NAD ) to Promote the Rejuvenation of the Peripheral Blood Immune Cells of Adults.",
     "org": "未标注",
     "status": "UNKNOWN",
     "statusRaw": "UNKNOWN",
     "statusClass": "unknown",
     "phase": "EARLY_PHASE1",
     "enroll": "10",
     "enrollType": "",
     "conditions": [
      "Enhance Immune Function"
     ],
     "interventions": [
      "NMN"
     ],
     "countries": [
      "China"
     ],
     "lastUpdate": "2023-08-21",
     "statusVerified": "2023-08-01",
     "startDate": "2023-08-01",
     "completionDate": "2024-12-01",
     "url": "https://clinicaltrials.gov/study/NCT05984550"
    },
    {
     "nct": "NCT02950441",
     "title": "Nicotinamide Adenine Dinucleotide and Skeletal Muscle Metabolic Phenotype",
     "org": "未标注",
     "status": "UNKNOWN",
     "statusRaw": "UNKNOWN",
     "statusClass": "unknown",
     "phase": "PHASE2",
     "enroll": "12",
     "enrollType": "",
     "conditions": [
      "Aging"
     ],
     "interventions": [
      "Nicotinamide Riboside",
      "Placebo"
     ],
     "countries": [
      "United Kingdom"
     ],
     "lastUpdate": "2017-06-07",
     "statusVerified": "2016-10-01",
     "startDate": "2016-06-01",
     "completionDate": "2019-09-01",
     "url": "https://clinicaltrials.gov/study/NCT02950441"
    }
   ]
  },
  "metformin": {
   "label": "二甲双胍",
   "count": 9,
   "trials": [
    {
     "nct": "NCT06975111",
     "title": "Focusing on the Menopausal Transition to Improve Mid-Life Women's Health",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "PHASE2 / PHASE3",
     "enroll": "200",
     "enrollType": "",
     "conditions": [
      "Menopause",
      "Menopause Hot Flashes",
      "Menopause Related Conditions",
      "Cardiovascular"
     ],
     "interventions": [
      "Metformin",
      "semaglutide",
      "Anti-hypertensives",
      "Lipid Lowering Medication"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-07-21",
     "statusVerified": "2026-07-01",
     "startDate": "2026-03-01",
     "completionDate": "2030-10-01",
     "url": "https://clinicaltrials.gov/study/NCT06975111"
    },
    {
     "nct": "NCT07092618",
     "title": "Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "PHASE2 / PHASE3",
     "enroll": "150",
     "enrollType": "",
     "conditions": [
      "Longevity",
      "GLP-1",
      "Geroscience",
      "Aging"
     ],
     "interventions": [
      "Metformin",
      "Rapamycin",
      "Naltrexone",
      "Vitamin C"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2025-07-30",
     "statusVerified": "2025-05-01",
     "startDate": "2024-12-17",
     "completionDate": "2025-08-01",
     "url": "https://clinicaltrials.gov/study/NCT07092618"
    },
    {
     "nct": "NCT07475546",
     "title": "Combination Gerotherapeutic Interventions for Healthspan Improvement",
     "org": "未标注",
     "status": "进行中（不再招募）",
     "statusRaw": "ACTIVE_NOT_RECRUITING",
     "statusClass": "active",
     "phase": "PHASE3",
     "enroll": "30",
     "enrollType": "",
     "conditions": [
      "Healthspan Improvement",
      "Aging",
      "Longevity"
     ],
     "interventions": [
      "Rapamycin",
      "Naltrexone",
      "Metformin",
      "NAD+"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-03-16",
     "statusVerified": "2026-03-01",
     "startDate": "2025-07-23",
     "completionDate": "2026-04-01",
     "url": "https://clinicaltrials.gov/study/NCT07475546"
    },
    {
     "nct": "NCT07788378",
     "title": "Metformin in Elderly Patients With Type 2 Diabetes and Muscle Strength, Muscle Mass, and Physical Function: Positive or Negative Correlation?",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "未标注分期",
     "enroll": "290",
     "enrollType": "",
     "conditions": [
      "Diabete Type 2",
      "Muscle Strength",
      "Muscle Mass",
      "Physical Function"
     ],
     "interventions": [
      "Metformin"
     ],
     "countries": [
      "China"
     ],
     "lastUpdate": "2026-08-26",
     "statusVerified": "2026-08-01",
     "startDate": "2024-11-11",
     "completionDate": "2024-12-24",
     "url": "https://clinicaltrials.gov/study/NCT07788378"
    },
    {
     "nct": "NCT07302932",
     "title": "Metformin and Molecular Aging in Prediabetes",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "NA",
     "enroll": "112",
     "enrollType": "",
     "conditions": [
      "Metformin, Prediabetes"
     ],
     "interventions": [
      "Metformin treatment",
      "Analyzed by qPCR for T/S ratio."
     ],
     "countries": [
      "India"
     ],
     "lastUpdate": "2025-12-24",
     "statusVerified": "2025-12-01",
     "startDate": "2023-02-01",
     "completionDate": "2025-01-30",
     "url": "https://clinicaltrials.gov/study/NCT07302932"
    },
    {
     "nct": "NCT03309007",
     "title": "A Double-Blind, Placebo-Controlled Trial of Anti-Aging, Pro-Autophagy Effects of Metformin in Adults With Prediabetes",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "PHASE3",
     "enroll": "25",
     "enrollType": "",
     "conditions": [
      "PreDiabetes",
      "Aging"
     ],
     "interventions": [
      "Metformin",
      "Placebo Oral Tablet"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2023-12-11",
     "statusVerified": "2023-12-01",
     "startDate": "2017-09-01",
     "completionDate": "2020-08-20",
     "url": "https://clinicaltrials.gov/study/NCT03309007"
    },
    {
     "nct": "NCT02432287",
     "title": "Metformin in Longevity Study (MILES).",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "PHASE4",
     "enroll": "16",
     "enrollType": "",
     "conditions": [
      "Aging"
     ],
     "interventions": [
      "Metformin",
      "Placebo"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2021-05-21",
     "statusVerified": "2021-05-01",
     "startDate": "2014-10-01",
     "completionDate": "2017-12-01",
     "url": "https://clinicaltrials.gov/study/NCT02432287"
    },
    {
     "nct": "NCT01765946",
     "title": "Metformin and Longevity Genes in Prediabetes",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "PHASE4",
     "enroll": "38",
     "enrollType": "",
     "conditions": [
      "Insulin Resistance",
      "Prediabetes",
      "Aging",
      "Inflammation"
     ],
     "interventions": [
      "Metformin",
      "placebo"
     ],
     "countries": [
      "Italy"
     ],
     "lastUpdate": "2013-03-13",
     "statusVerified": "2013-03-01",
     "startDate": "2010-06-01",
     "completionDate": "2013-03-01",
     "url": "https://clinicaltrials.gov/study/NCT01765946"
    },
    {
     "nct": "NCT03451006",
     "title": "Effect of Metformin on Frailty in 12 Subjects",
     "org": "未标注",
     "status": "已终止",
     "statusRaw": "TERMINATED",
     "statusClass": "terminated",
     "phase": "PHASE2",
     "enroll": "7",
     "enrollType": "",
     "conditions": [
      "Aging",
      "Inflammation",
      "Frailty"
     ],
     "interventions": [
      "Metformin",
      "Placebo"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2022-11-17",
     "statusVerified": "2022-10-01",
     "startDate": "2018-05-24",
     "completionDate": "2021-12-16",
     "url": "https://clinicaltrials.gov/study/NCT03451006"
    }
   ]
  },
  "rapamycin": {
   "label": "雷帕霉素 / mTOR",
   "count": 13,
   "trials": [
    {
     "nct": "NCT05237687",
     "title": "The Role of Sirolimus in Preventing Functional Decline in Older Adults",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "PHASE2",
     "enroll": "10",
     "enrollType": "",
     "conditions": [
      "Aging"
     ],
     "interventions": [
      "Sirolimus"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-06-25",
     "statusVerified": "2025-11-01",
     "startDate": "2026-03-31",
     "completionDate": "2028-01-01",
     "url": "https://clinicaltrials.gov/study/NCT05237687"
    },
    {
     "nct": "NCT06727305",
     "title": "MTOR Inhibitors in Older Adults",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "PHASE1 / PHASE2",
     "enroll": "60",
     "enrollType": "",
     "conditions": [
      "Aging"
     ],
     "interventions": [
      "Sirolimus 0.5 Mg Oral Tablet",
      "Sirolimus 1Mg Oral Tablet",
      "Sirolimus 2 MG Oral Tablet",
      "Everolimus 0.5 MG Oral Tablet"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-06-25",
     "statusVerified": "2026-06-01",
     "startDate": "2026-05-11",
     "completionDate": "2027-11-13",
     "url": "https://clinicaltrials.gov/study/NCT06727305"
    },
    {
     "nct": "NCT06658093",
     "title": "RESTOR: PK/PD mTORi Inhibition in Older Adults",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "EARLY_PHASE1",
     "enroll": "194",
     "enrollType": "",
     "conditions": [
      "Aging"
     ],
     "interventions": [
      "Rapamycin",
      "Everolimus",
      "Placebo"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-06-01",
     "statusVerified": "2026-05-01",
     "startDate": "2026-03-04",
     "completionDate": "2028-07-01",
     "url": "https://clinicaltrials.gov/study/NCT06658093"
    },
    {
     "nct": "NCT05949658",
     "title": "Rapalog Pharmacology (RAP PAC) Study",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "PHASE1",
     "enroll": "72",
     "enrollType": "",
     "conditions": [
      "Aging"
     ],
     "interventions": [
      "Sirolimus",
      "Everolimus"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-05-28",
     "statusVerified": "2026-02-01",
     "startDate": "2024-05-15",
     "completionDate": "2028-12-01",
     "url": "https://clinicaltrials.gov/study/NCT05949658"
    },
    {
     "nct": "NCT04742777",
     "title": "Effect of mTOR Inhibition & Other Metabolism Modulating Interventions on the Elderly [SubStudy Rapa & cMRI to Evaluate Cardiac Function]",
     "org": "未标注",
     "status": "进行中（不再招募）",
     "statusRaw": "ACTIVE_NOT_RECRUITING",
     "statusClass": "active",
     "phase": "PHASE2",
     "enroll": "20",
     "enrollType": "",
     "conditions": [
      "Aging"
     ],
     "interventions": [
      "rapamycin"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-09-23",
     "statusVerified": "2026-09-01",
     "startDate": "2022-02-01",
     "completionDate": "2026-10-16",
     "url": "https://clinicaltrials.gov/study/NCT04742777"
    },
    {
     "nct": "NCT07354620",
     "title": "A Pilot Study on Reverse Aging (The REVERSE Study)",
     "org": "未标注",
     "status": "进行中（不再招募）",
     "statusRaw": "ACTIVE_NOT_RECRUITING",
     "statusClass": "active",
     "phase": "EARLY_PHASE1",
     "enroll": "52",
     "enrollType": "",
     "conditions": [
      "Aging"
     ],
     "interventions": [
      "Rapamycin (Tablets)",
      "Prolon diet"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-01-21",
     "statusVerified": "2026-01-01",
     "startDate": "2025-02-15",
     "completionDate": "2026-05-01",
     "url": "https://clinicaltrials.gov/study/NCT07354620"
    },
    {
     "nct": "NCT05836025",
     "title": "Effect of Rapamycin in Ovarian Aging",
     "org": "未标注",
     "status": "进行中（不再招募）",
     "statusRaw": "ACTIVE_NOT_RECRUITING",
     "statusClass": "active",
     "phase": "PHASE2",
     "enroll": "50",
     "enrollType": "",
     "conditions": [
      "Perimenopausal"
     ],
     "interventions": [
      "Rapamycin",
      "Placebo"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2025-12-26",
     "statusVerified": "2025-12-01",
     "startDate": "2023-06-01",
     "completionDate": "2026-09-01",
     "url": "https://clinicaltrials.gov/study/NCT05836025"
    },
    {
     "nct": "NCT05835999",
     "title": "Everolimus Aging Study",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "PHASE2",
     "enroll": "106",
     "enrollType": "",
     "conditions": [
      "Aging",
      "Insulin Resistance"
     ],
     "interventions": [
      "Everolimus 0.5 MG once per day",
      "Everolimus 5 MG once per week",
      "Placebo once per day",
      "Placebo once per week"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-09-04",
     "statusVerified": "2026-09-01",
     "startDate": "2023-03-24",
     "completionDate": "2026-07-22",
     "url": "https://clinicaltrials.gov/study/NCT05835999"
    },
    {
     "nct": "NCT06550271",
     "title": "The Bioavailability of Compounded and Generic Rapamycin in Normative Aging Individuals",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "未标注分期",
     "enroll": "67",
     "enrollType": "",
     "conditions": [
      "Aging"
     ],
     "interventions": [
      "Rapamycin"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2024-08-13",
     "statusVerified": "2024-08-01",
     "startDate": "2023-04-25",
     "completionDate": "2023-12-15",
     "url": "https://clinicaltrials.gov/study/NCT06550271"
    },
    {
     "nct": "NCT04488601",
     "title": "Participatory Evaluation (of) Aging (With) Rapamycin (for) Longevity Study",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "PHASE2",
     "enroll": "129",
     "enrollType": "",
     "conditions": [
      "Aging"
     ],
     "interventions": [
      "Rapamycin",
      "Placebo"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2024-01-24",
     "statusVerified": "2022-10-01",
     "startDate": "2020-01-01",
     "completionDate": "2023-12-30",
     "url": "https://clinicaltrials.gov/study/NCT04488601"
    },
    {
     "nct": "NCT04608448",
     "title": "Topical-RAPA Use in Inflammation Reversal and Re-setting the Epigenetic Clock",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "EARLY_PHASE1",
     "enroll": "22",
     "enrollType": "",
     "conditions": [
      "Aging",
      "Epigenetics",
      "Inflammatory Mediators"
     ],
     "interventions": [
      "Rapamycin Topical Ointment",
      "Placebo"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2023-07-19",
     "statusVerified": "2023-06-01",
     "startDate": "2021-04-28",
     "completionDate": "2022-04-15",
     "url": "https://clinicaltrials.gov/study/NCT04608448"
    },
    {
     "nct": "NCT02874924",
     "title": "Effect of mTOR Inhibition and Other Metabolism Modulating Interventions on the Elderly",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "PHASE2",
     "enroll": "34",
     "enrollType": "",
     "conditions": [
      "Aging"
     ],
     "interventions": [
      "Rapamycin",
      "Placebo",
      "Rapamycin"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2018-12-04",
     "statusVerified": "2018-03-01",
     "startDate": "2016-06-01",
     "completionDate": "2018-09-01",
     "url": "https://clinicaltrials.gov/study/NCT02874924"
    },
    {
     "nct": "NCT01649960",
     "title": "Exercise and Low-Dose Rapamycin in Older Adults With CAD:Cardiac Rehabilitation And Rapamycin in Elderly (CARE) Trial",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "PHASE1",
     "enroll": "13",
     "enrollType": "",
     "conditions": [
      "Aging",
      "CAD"
     ],
     "interventions": [
      "Rapamycin"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2016-12-07",
     "statusVerified": "2016-12-01",
     "startDate": "2012-08-01",
     "completionDate": "2015-12-01",
     "url": "https://clinicaltrials.gov/study/NCT01649960"
    }
   ]
  },
  "spermidine": {
   "label": "亚精胺 / 自噬",
   "count": 2,
   "trials": [
    {
     "nct": "NCT07675200",
     "title": "Effects of Miricell Supplementation on Biomarkers of Healthy Aging and Autophagy",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "NA",
     "enroll": "70",
     "enrollType": "",
     "conditions": [
      "Autophagy",
      "Healthy Aging"
     ],
     "interventions": [
      "Spermidine",
      "Placebo"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-06-30",
     "statusVerified": "2026-06-01",
     "startDate": "2026-01-09",
     "completionDate": "2026-09-01",
     "url": "https://clinicaltrials.gov/study/NCT07675200"
    },
    {
     "nct": "NCT07202403",
     "title": "Iterative Design Trial to Assess Dietary Supplements and Other Aging-targeted Therapies",
     "org": "未标注",
     "status": "定向邀请入组",
     "statusRaw": "ENROLLING_BY_INVITATION",
     "statusClass": "active",
     "phase": "NA",
     "enroll": "10",
     "enrollType": "",
     "conditions": [
      "Aging",
      "Longevity"
     ],
     "interventions": [
      "Spermidine"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2025-10-01",
     "statusVerified": "2025-09-01",
     "startDate": "2025-09-01",
     "completionDate": "2031-09-01",
     "url": "https://clinicaltrials.gov/study/NCT07202403"
    }
   ]
  },
  "gerotherapeutics": {
   "label": "其他 gerotherapeutics",
   "count": 19,
   "trials": [
    {
     "nct": "NCT07462767",
     "title": "Precision Microbiota Interventions for Senoreduction Trial",
     "org": "未标注",
     "status": "尚未开始招募",
     "statusRaw": "NOT_YET_RECRUITING",
     "statusClass": "recruiting",
     "phase": "PHASE1 / PHASE2",
     "enroll": "160",
     "enrollType": "",
     "conditions": [
      "HIV Infections",
      "Alcohol Drinking",
      "Aging",
      "Immunosenescence"
     ],
     "interventions": [
      "Limosilactobacillus reuteri",
      "Blueberry extract"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-10-01",
     "statusVerified": "2026-09-01",
     "startDate": "2026-10-01",
     "completionDate": "2029-12-01",
     "url": "https://clinicaltrials.gov/study/NCT07462767"
    },
    {
     "nct": "NCT07760506",
     "title": "The Effects of Quercefit® and Ubiqsome™ in Mitigating Inflammation and Promoting Metabolic Health",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "NA",
     "enroll": "60",
     "enrollType": "",
     "conditions": [
      "Healthy Aging",
      "Inflammaging",
      "Metabolic Health",
      "Quercetin"
     ],
     "interventions": [
      "Quercetin (dietary supplement)",
      "Coenzyme Q10",
      "Rice Flour"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-09-17",
     "statusVerified": "2026-09-01",
     "startDate": "2026-09-18",
     "completionDate": "2028-08-01",
     "url": "https://clinicaltrials.gov/study/NCT07760506"
    },
    {
     "nct": "NCT07719088",
     "title": "Psilocybin Effects on Healthy Aging Biomarkers and Purpose in Life",
     "org": "未标注",
     "status": "尚未开始招募",
     "statusRaw": "NOT_YET_RECRUITING",
     "statusClass": "recruiting",
     "phase": "PHASE1",
     "enroll": "50",
     "enrollType": "",
     "conditions": [
      "Aging",
      "Longevity",
      "Biomarkers of Aging"
     ],
     "interventions": [
      "Psilocybin (Usona Institute)"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2026-08-17",
     "statusVerified": "2026-08-01",
     "startDate": "2026-12-01",
     "completionDate": "2028-12-01",
     "url": "https://clinicaltrials.gov/study/NCT07719088"
    },
    {
     "nct": "NCT07596576",
     "title": "Sheba Healthspan Research Population (SHARP) Trial - Sheba Longevity Center Diagnostic and Intervention Protocol to Lower Biological Age in Older Adults",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "NA",
     "enroll": "1500",
     "enrollType": "",
     "conditions": [
      "Healthy Aging",
      "Healthspan",
      "Biological Age",
      "Intrinsic Capacity"
     ],
     "interventions": [
      "healthspan personalized protocol",
      "Control"
     ],
     "countries": [
      "Israel"
     ],
     "lastUpdate": "2026-05-19",
     "statusVerified": "2026-05-01",
     "startDate": "2024-03-01",
     "completionDate": "2027-12-01",
     "url": "https://clinicaltrials.gov/study/NCT07596576"
    },
    {
     "nct": "NCT07456449",
     "title": "Collagen Peptides and Cellular Aging",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "NA",
     "enroll": "125",
     "enrollType": "",
     "conditions": [
      "Longevity",
      "Healthy Aging",
      "Biological Ageing"
     ],
     "interventions": [
      "Collagen peptides",
      "Maltodextrin (Placebo)"
     ],
     "countries": [
      "Austria"
     ],
     "lastUpdate": "2026-05-05",
     "statusVerified": "2026-01-01",
     "startDate": "2026-04-22",
     "completionDate": "2028-08-01",
     "url": "https://clinicaltrials.gov/study/NCT07456449"
    },
    {
     "nct": "NCT07524478",
     "title": "A Randomized Controlled Trial of a Multi-domain Smartphone Intervention Incorporating Generative AI for Healthy Older Adults",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "NA",
     "enroll": "300",
     "enrollType": "",
     "conditions": [
      "Healthy Longevity"
     ],
     "interventions": [
      "Multidomain intervention",
      "Control"
     ],
     "countries": [
      "Japan"
     ],
     "lastUpdate": "2026-04-16",
     "statusVerified": "2026-04-01",
     "startDate": "2026-03-10",
     "completionDate": "2027-12-31",
     "url": "https://clinicaltrials.gov/study/NCT07524478"
    },
    {
     "nct": "NCT07466290",
     "title": "L-serine and Strength Training in the Elderly",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "NA",
     "enroll": "126",
     "enrollType": "",
     "conditions": [
      "Brain Health",
      "Longevity",
      "Cognitive Performance",
      "Strength Training Effects"
     ],
     "interventions": [
      "Strength training",
      "L-serine supplementation",
      "Control (cornstarch)"
     ],
     "countries": [
      "Austria"
     ],
     "lastUpdate": "2026-03-12",
     "statusVerified": "2026-02-01",
     "startDate": "2026-03-01",
     "completionDate": "2028-12-01",
     "url": "https://clinicaltrials.gov/study/NCT07466290"
    },
    {
     "nct": "NCT07113860",
     "title": "Reframing Expectations About Aging - Physical Activity and Inclusive Reappraisal",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "NA",
     "enroll": "342",
     "enrollType": "",
     "conditions": [
      "Self-perceptions of Aging",
      "Physical Activity"
     ],
     "interventions": [
      "Views on Aging Intervention",
      "Projecte Moviment"
     ],
     "countries": [
      "Spain"
     ],
     "lastUpdate": "2025-08-19",
     "statusVerified": "2025-08-01",
     "startDate": "2025-07-28",
     "completionDate": "2027-10-01",
     "url": "https://clinicaltrials.gov/study/NCT07113860"
    },
    {
     "nct": "NCT06882434",
     "title": "Holistic Integration for Healthy Longevity and Aging in Place",
     "org": "未标注",
     "status": "尚未开始招募",
     "statusRaw": "NOT_YET_RECRUITING",
     "statusClass": "recruiting",
     "phase": "NA",
     "enroll": "600",
     "enrollType": "",
     "conditions": [
      "Cognitive Decline",
      "Sarcopenia",
      "Depression Disorders",
      "Nutrition Disorder"
     ],
     "interventions": [
      "Local intervention program",
      "Referral Process",
      "Telehealth Education & Digital Integration"
     ],
     "countries": [],
     "lastUpdate": "2025-03-25",
     "statusVerified": "2025-03-01",
     "startDate": "2025-03-15",
     "completionDate": "2028-12-31",
     "url": "https://clinicaltrials.gov/study/NCT06882434"
    },
    {
     "nct": "NCT06666660",
     "title": "Daily Intake of Multivitamin & Mineral Supplementation Effects on Biological Age of Relatively Healthy Middle-aged Individuals",
     "org": "未标注",
     "status": "招募中",
     "statusRaw": "RECRUITING",
     "statusClass": "recruiting",
     "phase": "NA",
     "enroll": "400",
     "enrollType": "",
     "conditions": [
      "Relatively Healthy Volunteers"
     ],
     "interventions": [
      "Multivitamin/Mineral supplements",
      "Placebo"
     ],
     "countries": [
      "Singapore"
     ],
     "lastUpdate": "2024-10-30",
     "statusVerified": "2024-10-01",
     "startDate": "2024-09-23",
     "completionDate": "2025-06-30",
     "url": "https://clinicaltrials.gov/study/NCT06666660"
    },
    {
     "nct": "NCT04195399",
     "title": "A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery",
     "org": "未标注",
     "status": "进行中（不再招募）",
     "statusRaw": "ACTIVE_NOT_RECRUITING",
     "statusClass": "active",
     "phase": "PHASE2",
     "enroll": "31",
     "enrollType": "",
     "conditions": [
      "Desmoid Fibromatosis",
      "Recurrent Desmoid Fibromatosis",
      "Unresectable Desmoid Fibromatosis"
     ],
     "interventions": [
      "Biospecimen Collection",
      "Computed Tomography",
      "Echocardiography Test",
      "Magnetic Resonance Imaging"
     ],
     "countries": [
      "Australia",
      "Canada",
      "New Zealand",
      "Puerto Rico",
      "United States"
     ],
     "lastUpdate": "2026-10-01",
     "statusVerified": "2026-09-01",
     "startDate": "2020-10-07",
     "completionDate": "2032-12-31",
     "url": "https://clinicaltrials.gov/study/NCT04195399"
    },
    {
     "nct": "NCT07723339",
     "title": "BIOANCIENT_EX: Effects of a Physical Exercise Program in Centenarians of the BIOANCIENT Cohort: A Randomized Clinical Trial.",
     "org": "未标注",
     "status": "定向邀请入组",
     "statusRaw": "ENROLLING_BY_INVITATION",
     "statusClass": "active",
     "phase": "NA",
     "enroll": "60",
     "enrollType": "",
     "conditions": [
      "Aging",
      "Cellular Senescence",
      "Biomarkers / Blood",
      "Exercise"
     ],
     "interventions": [
      "Exercise"
     ],
     "countries": [
      "Spain"
     ],
     "lastUpdate": "2026-09-01",
     "statusVerified": "2026-08-01",
     "startDate": "2026-08-13",
     "completionDate": "2027-12-01",
     "url": "https://clinicaltrials.gov/study/NCT07723339"
    },
    {
     "nct": "NCT06990256",
     "title": "Evaluation of Urolithin A and Fisetin on Improving Sleep and Aging Biomarkers",
     "org": "未标注",
     "status": "进行中（不再招募）",
     "statusRaw": "ACTIVE_NOT_RECRUITING",
     "statusClass": "active",
     "phase": "NA",
     "enroll": "83",
     "enrollType": "",
     "conditions": [
      "Sleep Disorder",
      "Aging"
     ],
     "interventions": [
      "Fisetin intervention",
      "Placebo",
      "Urolithin A intervention"
     ],
     "countries": [
      "China"
     ],
     "lastUpdate": "2026-08-10",
     "statusVerified": "2025-09-01",
     "startDate": "2025-09-16",
     "completionDate": "2026-12-30",
     "url": "https://clinicaltrials.gov/study/NCT06990256"
    },
    {
     "nct": "NCT04951700",
     "title": "Aging and Disease Course: Contributions to Lifespan Neurobiology of Schizophrenia",
     "org": "未标注",
     "status": "进行中（不再招募）",
     "statusRaw": "ACTIVE_NOT_RECRUITING",
     "statusClass": "active",
     "phase": "未标注分期",
     "enroll": "194",
     "enrollType": "",
     "conditions": [
      "Schizophrenia",
      "Aging",
      "Disease Course",
      "Biomarker"
     ],
     "interventions": [
      "Other"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2025-08-21",
     "statusVerified": "2025-08-01",
     "startDate": "2021-07-01",
     "completionDate": "2027-04-30",
     "url": "https://clinicaltrials.gov/study/NCT04951700"
    },
    {
     "nct": "NCT07114536",
     "title": "Evaluation of the Efficacy of Calcium a -Ketoglutarate(AKG-Ca) in Improving Human Aging",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "NA",
     "enroll": "34",
     "enrollType": "",
     "conditions": [
      "Aging"
     ],
     "interventions": [
      "Calcium-a-ketoglutarate",
      "Placebo(starch)"
     ],
     "countries": [
      "China"
     ],
     "lastUpdate": "2026-09-16",
     "statusVerified": "2026-09-01",
     "startDate": "2025-08-20",
     "completionDate": "2025-11-30",
     "url": "https://clinicaltrials.gov/study/NCT07114536"
    },
    {
     "nct": "NCT05601102",
     "title": "danceSing Care Evaluation: Testing the Effectiveness",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "NA",
     "enroll": "34",
     "enrollType": "",
     "conditions": [
      "Older Adults",
      "Healthy Aging",
      "Aging",
      "Quality of Life"
     ],
     "interventions": [
      "danceSing Care"
     ],
     "countries": [
      "United Kingdom"
     ],
     "lastUpdate": "2025-05-20",
     "statusVerified": "2025-05-01",
     "startDate": "2023-03-20",
     "completionDate": "2023-08-20",
     "url": "https://clinicaltrials.gov/study/NCT05601102"
    },
    {
     "nct": "NCT01745263",
     "title": "DO-HEALTH / Vitamin D3 - Omega3 - Home Exercise - Healthy Ageing and Longevity Trial",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "PHASE3",
     "enroll": "2157",
     "enrollType": "",
     "conditions": [
      "Improve Healthy Ageing in Seniors; Prevent Disease at Older Age"
     ],
     "interventions": [
      "Vitamin D3",
      "Omega 3 fatty acids",
      "Strength Home Exercise",
      "Flexibility Home Exercise"
     ],
     "countries": [
      "Austria",
      "France",
      "Germany",
      "Portugal",
      "Switzerland"
     ],
     "lastUpdate": "2018-08-09",
     "statusVerified": "2018-08-01",
     "startDate": "2012-12-20",
     "completionDate": "2018-01-19",
     "url": "https://clinicaltrials.gov/study/NCT01745263"
    },
    {
     "nct": "NCT00818311",
     "title": "Skin Safety Profile of Different Exposure to the Light Emitting Diode (LED) in Healthy Subjects",
     "org": "未标注",
     "status": "已完成",
     "statusRaw": "COMPLETED",
     "statusClass": "completed",
     "phase": "NA",
     "enroll": "100",
     "enrollType": "",
     "conditions": [
      "Radiation Tolerance",
      "Skin Aging",
      "Rhytids"
     ],
     "interventions": [
      "LED GentleWaves®"
     ],
     "countries": [
      "United States"
     ],
     "lastUpdate": "2009-01-07",
     "statusVerified": "2009-01-01",
     "startDate": "2008-06-01",
     "completionDate": "2008-12-01",
     "url": "https://clinicaltrials.gov/study/NCT00818311"
    },
    {
     "nct": "NCT03734419",
     "title": "The Use of Aging Biomarkers in Saliva, Based on DNA Methylation Status in Elovl2 to Predict Biological Age",
     "org": "未标注",
     "status": "已撤回",
     "statusRaw": "WITHDRAWN",
     "statusClass": "terminated",
     "phase": "未标注分期",
     "enroll": "0",
     "enrollType": "",
     "conditions": [
      "Healthy"
     ],
     "interventions": [],
     "countries": [],
     "lastUpdate": "2023-12-21",
     "statusVerified": "2023-12-01",
     "startDate": "2019-12-01",
     "completionDate": "2021-12-01",
     "url": "https://clinicaltrials.gov/study/NCT03734419"
    }
   ]
  }
 }
}